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Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. In this study, researchers compared Feraheme treatment with that of ferric carboxymaltose (the active drug in Injectafer). Potential injection site discoloration has happened. People who are ongoingcancer treatmentwithradiation therapyor takingchemotherapy drugsmay be more susceptible toside effects. What is the latest research on the form of cancer Jimmy Carter has? The infusion will take between 15-30 minutes if it is given in. Use Venofer as ordered by your doctor. Your doctor will do laboratory tests to monitor your response. A variety of tests can diagnose iron deficiency anemia. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. fever. Pain, swelling, or redness at the injection site may occur. What is Venofer? Many people believe they are suffering fromside effectsand may actually be suffering from anothermedical condition, such as havingdifficulty breathingorshortness of breath, which could be a heartattack. Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft). Once inside your body, ferric carboxymaltose releases iron into your system. <> How long it takes for the bodyto break down the meds matters and some peoples bodies simply take longer than others. If you have questions about side effects, call your doctor. It belongs to a class of medications known as iron replacement products. For people weighing less than 50 kg, administer Injectafer in two doses of 15 mg/kg of body weight, at least 7 days apart. Side effects are uncomfortable reactions to medications or drugs. Allergic reactions typically occur the first time your body is exposed to a drug. Heart failure: Could a low sodium diet sometimes do more harm than good? If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre taking Injectafer. Symptoms of a severe allergic reaction can include: Because of the risk of allergic reaction with Injectafer, your healthcare professional will monitor you for at least 30 minutes after you get each dose of the drug. Review our medical disclaimer. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. For some people, after receiving one treatment course (two doses) of Injectafer, their IDA is resolved. There are 2 tests that your doctor will likely The body cannot metabolize such a high dose fast enough, so it ends up affecting a part of the body it wasnt intended to, such as the stomach. Call your doctor right away if you have serious side effects. Do not double the dose to catch up. Injectafer helps to treat IDA by providing an iron infusion directly into your body. The factors influencing how longside effectslast may not provide the answer most are looking for, but it does explain why some people cant take certain medications because theside effectsareunbearable. Side effectsare uncomfortable reactions to medications or drugs. But its only approved for use in people with CKD who may or may not need dialysis. If this happens, you may need to get another treatment course of Injectafer, if your doctor recommends it for you. Data on file, American Regent, Inc. 1. endobj Learn more about the types of tests and treatment. Injectafer contains the active drug ferric carboxymaltose, while Venofer contains the active drug iron sucrose. Some people may also experience skin irritation from the adhesive tape and other medical equipment used during the procedure. Venofer (iron sucrose injection, USP) Rx Only DESCRIPTION Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use. Do not flush down a toilet or pour down a drain unless you are told to do so. Generic name: iron sucrose (injection) [EYE-urn-SOO-krose] Call your doctor for medical advice about side effects. Grapefruitjuice may be healthy for people to drink, but it can cause someseriousside effects. You should always consult your doctor or another healthcare professional before taking any medication. Amounts of iron ingested by the infant would be normal and are not expected to cause any adverse effects in breastfed infants. Orofer S 50 Injection 1 Injection in 1 Packet 147. Storage Condition Store in a cool and dry place protected from light. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. If you have iron deficiency anemia (IDA), there are certain foods you can eat that may help increase your iron levels. %PDF-1.3 Boxed warnings alert doctors and patients about drug effects that may be dangerous. Its FDA-approved to treat iron deficiency anemia (IDA) in adults. Injectafer and Feraheme can cause very similar side effects, but some different ones as well. The drug helps increase your hemoglobin level back to a value thats within the normal range. A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. This site is intended for use only by US patients. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Some may be a better fit for you than others. But for other people, doing so could lead to having too much iron in their body. WARNINGS/CAUTIONS: Serious hypersensitivity reactions, including anaphylactic-type reactions (itching, hives, swelling, wheezing, difficulty breathing, fainting and/or other allergy symptoms), some of which have been life threatening and fatal, have happened in patients receiving Venofer. And babies born to those who took Injectafer during pregnancy didnt have any major congenital anomalies (also sometimes called birth defects). There are currently no generic forms of either drug. Injectafer and Feraheme are both brand-name drugs. Now I've just got mild nausea and have felt faint/dizzy a few times which is rare for me. Feraheme is also approved to treat IDA in adults who either didnt have improvement in their IDA or had side effects with iron treatment thats taken by mouth. During pregnancy, this medication should be used only when clearly needed. Brand-name medications usually cost more than generics. Some drugs may have another patient information leaflet. Be ready to tell or show what was taken, how much, and when it happened. The dosing for iron replacement treatment in pediatric patients less than 2 years old with Peritoneal or Hemodialysis-Dependent CKD or Non-Dialysis-Dependent CKD have not been established. 3 0 obj But for other people, their IDA returns after treatment with Injectafer. These symptoms can include: While youre taking Injectafer, your doctor will monitor your phosphorus levels if youre at risk for hypophosphatemia. If you have any questions about Venofer, please talk with your doctor, nurse, pharmacist, or other health care provider. Do not start, stop, or change the dose of any drug without checking with your doctor. Allergic reaction As with most drugs, some people can have an allergic reaction after taking Injectafer. Your body then uses the iron from Injectafer to make hemoglobin and new RBCs. The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. If youre not sure if youll need to get prior authorization for Injectafer, contact your insurance company. Dizziness. Tell your doctor if you are taking iron supplements or other iron-based oral medications, such as: This list is not complete. However, Injectafer has been studied for use in children with iron deficiency anemia (IDA). Laboratory tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be performed periodically to monitor your progress or check for side effects. This is a sudden response affecting the entire body, which sometimes happens to people who are allergic to peanuts or beestings. In this group, after 35 days of treatment: In clinical studies, Injectafer was effective in treating IDA in adults with CKD who didnt require dialysis. Dr. Colby is alsothe Founder of Sequencing.com and the authorofOutsmart Your Genes. Keep all drugs in a safe place. Cholesterolmedication may reduce the risk of a stroke but it can decrease the quality of life for some people but causingweight gain, dizziness, nausea, and musclepain. These changes could help improve your anemia on a long-term basis. Symptoms of overdosage include drowsiness, mental confusion, dizziness, diarrhea and vomiting etc. Its not currently available in generic form. The iron released by this drug does pass into human breast milk. Instead, youll start by receiving just one treatment course of Injectafer. Some products that may interact with this drug include: vitamin products, other iron-containing products. Its not known if Injectafer is safe to take during pregnancy. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. For example, some people with anemia have extreme fatigue (lack of energy), which can make it hard for them to exercise. Only 10 mg may be excreted by the body the next time it goes through the liver, and possibly only 5 mg the nextpass. Follow all instructions closely. Venofer pregnancy and breastfeeding warnings. muscle pain. Hemoglobin is a protein thats found in your RBCs. signs of inflammation in the lining of your stomach - pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, fever. Youll receive doses of either drug by a healthcare professional at a medical facility. Injectafer isnt known to interact with any other medications, herbs, supplements, or foods. If either is present, do not use the liquid. US residents can call their local poison control center at 1-800-222-1222. If youre concerned about weight changes while youre taking Injectafer, talk with your doctor. This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. . I had my first infusion of 1gm 10 days ago. Not all possible drug interactions are listed here. Why is the range so wide? Both Injectafer and Feraheme belong to a class of medications known as iron replacement products. Injectafer can cause low blood levels of phosphorus, which is a condition called hypophosphatemia. fruit-like breath odor increased hunger or thirst increased urination lack or loss of strength pain or redness at the injection site pale skin at the injection site runny nose, sneezing sore throat unexplained weight loss Rare Burning, dry, or itching eyes discharge or excessive tearing There are different types of anemia, but IDA is the most common type. But keep in mind that in this study, delayed allergic reaction only occurred in one person. Its not known how common delayed allergic reaction might be in other people using Injectafer. fluid retention, especially in your arms, legs, or feet, people who took Feraheme had their hemoglobin level increase, on average, by 1.38 grams per deciliter (g/dL), people who took ferric carboxymaltose had their hemoglobin level increase, on average, by 1.63 g/dL, having strange cravings to eat items that arent food, such as ice, people who took Injectafer had their hemoglobin level increase, on average, by 1.6 grams per deciliter (g/dL), people who kept taking iron by mouth had their hemoglobin level increase, on average, by 0.8 g/dL, people who took Injectafer had their hemoglobin level increase, on average, by 2.9 g/dL, people who took the other intravenous iron product had their hemoglobin level increase, on average, by 2.2 g/dL, people who took Injectafer had their hemoglobin level increase by an average of 1.1 g/dL, people who took Venofer had their hemoglobin level increase by an average of 0.9 g/dL, cannot tolerate or have shown a poor response to oral iron, or, have been diagnosed with chronic kidney disease (CKD) that is non-dialysis dependent. 12 Medicines That Could Help, List Venofer Vial side effects by likelihood and severity. If you need financial support to pay for Injectafer, or if you need help understanding your insurance coverage, help is available. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. The insurance company will review the prior authorization request and decide if the drug will be covered. Knowing how longside effectslast can help with the decision on whether to use a particulardrug. Your doctor may also recommend that you take iron supplements by mouth (if you havent tried these supplements in the past). Should I avoid certain foods while taking Venofer Vial? Call your doctor right away if you have chest pain, cough or the need to cough, dizziness, passing out, shortness of breath, sweating, or throat tightness. Read all information given to you. It can be given as a slow injection over 2 to 5 minutes or as an infusion. Its not known how often people taking a treatment other than Injectafer had diarrhea. Youll receive doses of Injectafer from a healthcare professional at a medical facility. Theseeffects of medicine on thebodycan also lead to medication non-compliance and worsening of themedical conditionthey are meant to treat. After 5 weeks of treatment: This study didnt determine if either drug was better than the other. The researchers looked to see how well each drug worked to increase peoples hemoglobin level. Usually, but not always, the bigger a person is the slower it takes for drugs to break down and leave the body. (One treatment course includes two doses of the drug.) But you likely wont feel the drug working inside of you. Other drugs are available that can treat iron deficiency anemia (IDA). Evenbirth controlcan lead to severeside effectslike bloodclots. Other side effects include: Common (may affect up to 1 in 10 users) Temporary taste changes (especially metallic taste) Low blood pressure or high blood pressure. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Notify your healthcare provider of all medical conditions and any medications, including supplements you are taking. Seriousside effectsshould be reported to a physician and/orPharmDfor medical advice. This information is not specific medical advice and does not replace information you receive from the healthcare provider. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Very bad and sometimes deadly allergic side effects have rarely happened. For instance, someone with lowblood pressuremay receive a medication to prevent migraines that lowersblood pressure, this may causeseriousside effects. In clinical trials,. TheNational Instituteof Health (NIH) and the U.S.Food and Drug Administration(FDA) monitor the side effectsof new and approved medications to ensure safety. If administering via IV infusion, up to 750 mg of Injectafer should be diluted in no more than 250 mL of sterile 0.9% sodium chloride solution (NaCl). xmq92\Kz!yIP}2~(?c/JUCK2~o_N=>K$o/_7'Z+nRkKM^y{u|ZFh$v}]O~vfo=.GowGFodVj-[-~x]Kg~9H'%h={OX/#S|Mc~|]_2nv`wwotn/+$G[{hGrP}sbZG-RGf#l~~l|Qnccml_iPy]G\17c,yPF[28z&I'+B(?rrvi,G?}/;'?;pm>?.i42ONmk~ai_u0z9o_? Venofer may cause serious side effects including: problems with your dialysis vein access point, chest pain, severe headache, blurred vision, pounding in your neck or ears, lightheadedness, pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, and fever Get medical help right away, if you have any of the symptoms listed above. If that happens, and your doctor thinks Injectafer is a good treatment option for you, you can receive another treatment course of the drug. Most people will metabolize medication by half every time it circulates the body. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Below are examples of these side effects. These tests will help make sure Injectafer is working to treat your iron deficiency anemia (IDA). Usually, when drugs may cause an immune system reaction like this, its a concern with your first dose of the drug. If you have questions about the best diet for you during Injectafer treatment, talk with your doctor. (A class of medications describes a group of drugs that work in the same way.). Tell all of your health care providers that you take Venofer. You can also write a reminder on your calendar. The potential side effects of Daxxify are nearly identical to that of Botox bruising, headaches, and droopy eyelids with one big difference: They could last longer. With IV infusion, the drug is given as a slow drip into your vein over a period of time. If you think there has been an overdose, call your poison control center or get medical care right away. Your doctor will go over your As described just above in the Allergic reaction section, some people may have an allergic reaction after getting a dose of Injectafer. Common MRI side effects include dizziness, anxiety, headache, nausea, hearing loud noises, and feeling chilled or hot in the MRI scanner. (A medication class describes a group of drugs that work in the same way.). The drug helps increase your hemoglobin level back to a value thats within the normal range. These lists contain examples of serious side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). Spacing your Injectafer doses out at least 7 days helps to reduce your risk of side effects. Which tests can diagnose iron deficiency anemia? Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. These side effects can range from being mild to severe. Effectiveness of Injectafer compared with iron thats taken by mouth. Consult your doctor before breast-feeding. You may report side effects to the FDA at 1-800-332-1088. Serious side effects should be reported to a physician and/or PharmD for medical advice. administered at your doctors office or an infusion center. Hes an expert in genetic testing, genetic analysis, andprecision medicine. For instance, there are some experts who believe there are long-lastingside effectsfromCOVIDthat were not aware of just yet. Side effects like nausea and low blood pressure are common with most iron infusions. In the studies, peoples hemoglobin level was measured to check for improvement in their anemia. Once you have waited for 30 minutes after the injection, you may go home, providing you are feeling well. However, since peoples bodies react so differently to drugs, they often have to change their stance on certaindrugs. Fortunately, knowing how longside effectslast can help those suffering know what to donext. But you dont necessarily need to eat these foods unless your doctor tells you to do so. A healthcare provider will give you this injection. (A medication class is a group of medications that work in a similar way.). Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Follow your doctor's directions carefully. You may report side effects to Health Canada at 1-866-234-2345. Injectafer is a brand-name prescription drug. Iron infusions are given directly into a vein. Theyll recommend how to manage your condition. Suffering from somemedical conditionsput people at risk fordrugside effectsof medications for other health concerns. For more information about taking Injectafer during pregnancy, see the section Injectafer and pregnancy above. Infusion times range from less than 20 minutes to up to 4 hours. This can be very helpful in . It is very important that your doctor check you closely while you are receiving this medicine. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. So the goal of IDA treatment with Injectafer is to bring your hemoglobin level back to a value thats within normal range. Always review your medical history with the treatingphysician. The next time the doctor prescribesprescription medication, ask aboutcommonside effectsand if they are known to last a short or longtime. Before approving coverage for Injectafer, your insurance company may require you to get prior authorization. There isnt a known interaction between Injectafer and alcohol. With IDA, you have anemia (low red blood cell level) thats due to not having enough iron in your body. Side effects: DayQuil can cause side effects such as drowsiness, dizziness, nausea, vomiting, and stomach upset. It belongs to a class of medications called iron replacement products. 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These effects typically last between 7 and 11 hours. Taking a higher dose than needed can often lead to adverse effects. Vomiting. Iron sucrose can harm an unborn baby if you have a severe reaction to this medicine during your second or third trimester. This allows them to manage any side effects that you may have following your dose. However, diarrhea it isnt very common in people using Injectafer. treatment schedule in further detail. In the studies, peoples hemoglobin level was measured to check for improvement in their anemia. This document does not contain all possible drug interactions. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Its caused by your body not having enough iron, which is needed to make hemoglobin. Can diet help improve depression symptoms? But even if youre not at risk for the condition, your doctor may still monitor your phosphorus levels. If you miss an appointment for your Injectafer dose, youll need to call your doctors office. They have been a god send. (See also Notes section.). (IV iron is absorbed by the body more rapidly than oral iron.) Do not exceed 1,500 mg of iron per dosing course. Injectafer contains the active drug ferric carboxymaltose, while Feraheme contains the active drug ferumoxytol. Keep in mind that the risk of certain pregnancy-related problems can be increased if iron deficiency anemia (IDA) is left untreated. Talk with the doctor. Its because everyones body is different. Its possible to get rid of or reduce the severity ofside effects. Its not known if Injectafer is safe to use during pregnancy. This website is intended for use by US healthcare professionals only. Then the study was split into the following two groups, which are discussed below. fever. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.